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Parag G. Patil, M.D. Ph.D.

Neurosurgery, Neurology, Anesthesiology and Biomedical Engineering

Parag Patil, MD PhD

Restorative Neuroengineering Group
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PUBLICATIONS

Willsey MS, Collins KL, Conrad EC, Chubb HA, Patil PG: Diffusion tensor imaging reveals microstructural differences between subtypes of trigeminal neuralgia Neurosurgery. J Neurosurg: 2019. JNS19299.

Sankarasubramanian V, Harte SE, Chiravuri S, Harris RE, Brummett CM, Patil PG, Clauw DJ, Lempka SF: Objective Measures to Characterize the Physiological Effects of Spinal Cord Stimulation in Neuropathic Pain: A Literature Review. Neuromodulation 22: 127-148, 2019. PM30246905/30246905

Jackowiak E, Patil PG, Chou KL: The Deep Brain Stimulation “Twiddler Syndrome”. JAMA Neurol: 2019. PM30985873/30985873

Tabet A, Jensen MP, Parkins CC, Patil PG, Watts C, Scherman OA: Designing Next-Generation Local Drug Delivery Vehicles for Glioblastoma Adjuvant Chemotherapy: Lessons from the Clinic. Adv Healthc Mater 8(3): e1801391, 2019. PM30632715/30632715

Goutman S, Brown M, Glass J, Boulis N, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges L, Patil P, Sakowski S, Feldman E.: Long-term Phase 1/2 Intraspinal Stem Cell Transplantation Outcomes in ALS Annals of Clinical and Translational Neurology 5(6): 730-740, 2018. PMC5989736

Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG: Correction to: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. Neurocrit Care: 2018. PM30377909

Bari AA, Mikell CB, Abosch A, Ben-Haim S, Buchanan RJ, Burton AW, Carcieri S, Cosgrove GR, D’Haese PF, Daskalakis ZJ, Eskandar EN, Gerrard JL, Goodman WK, Greenberg BD, Gross RE, Hamani C, Kiss ZHT, Konrad P, Kopell BH, Krinke L, Langevin JP, Lozano AM, Malone D, Mayberg HS, Miller JP, Patil PG, Peichel D, Petersen EA, Rezai AR, Richardson RM, Riva-Posse P, Sankar T, Schwalb JM, Simpson HB, Slavin K, Stypulkowski PH, Tosteson T, Warnke P, Willie JT, Zaghloul KA, Neimat JS, Pouratian N, Sheth SA: Charting the road forward in psychiatric neurosurgery: proceedings of the 2016 American Society for Stereotactic and Functional Neurosurgery workshop on neuromodulation for psychiatric disorders. J Neurol Neurosurg Psychiatry 89: 886-896, 2018. PM29371415

Conrad EC, Mossner JM, Chou KL, Patil PG: Atlas-Independent, Electrophysiological Mapping of the Optimal Locus of Subthalamic Deep Brain Stimulation for the Motor Symptoms of Parkinson Disease. Stereotact Funct Neurosurg: 1-9, 2018. PM29791914

Bentley JN, Khalsa SSS, Kobylarek M, Schroeder KE, Chen K, Bergin IL, Tat DM, Chestek CA, Patil PG: A simple, inexpensive method for subcortical stereotactic targeting in nonhuman primates. J Neurosci Methods: 2018. PM29768185

Rajajee V, Williamson CA, Fontana RJ, Courey AJ, Patil PG: Noninvasive Intracranial Pressure Assessment in Acute Liver Failure. Neurocrit Care: 2018. PM29948998

Vaskov AK, Irwin ZT, Nason SR, Vu PP, Nu CS, Bullard AJ, Hill M, North N, Patil PG, Chestek CA: Cortical Decoding of Individual Finger Group Motions Using ReFIT Kalman Filter. Front Neurosci 12: 751, 2018. PM30455621/PMC6231049

Lempka SF, Patil PG: Innovations in spinal cord stimulation for pain. Curr Opin Biomed Eng 8: 51-60, 2018. PM30911705/PMC6430588

Holtzheimer P, Husain MM, Lisanby SH, Taylor SF, Whitworth LA, McClintock S, Slavin KV, Berman J, McKhann GM, Patil PG, Rittberg BR, Abosch A, Pandurangi AK, Holloway KL, Lam RW, Honey CR, Neimat JS, Henderson JM, DeBattista C, Rothschild AJ, Pilitsis JG, Espinoza RT, Petrides G, Mogilnter AY, Matthews K, Peichel D, Gross R, Hamani C, Lozano AM, Mayberg HS. Subcallosal Cingulate Deep Brain Stimulation for Treatment-Resistant Depression: A Multi-site, Randomized, Sham-Controlled Trial. Lancet Psych, 4:839-849. 2017. PM28988904

Dodani SS, Lu CW, Aldridge JW, Chou KL, Patil PG. A Computerized Microelectrode Recording to Magnetic Resonance Imaging Mapping System for Subthalamic Nucleus Deep Brain Stimulation Surgery. Oper Neurosurg, Aug 5 2017. PM28961898

Gebarski SS, Chiravuri S, Foerster BR, Patil PG. Microstructural mechanisms of analgesia in percutaneous cervical cordotomy revealed by diffusion tensor imaging. J Clin Neurosci, 45:311-314. 2017. PM28887076

Irwin ZT, Schroeder KE, Vu P, Bullard A, Tat D, Nu Chrono, Vaskov A, Nason S, Thompson D, Bentley JN, Patil PG, Chestek CA. Neural control of finger movement via intracortical brain-machine interface. J Neural Eng, 14:066004. 2017.PM28722685/PMC5737665

Rajajee V, Fontana RJ, Courey AJ, Patil PG. Protocol Based Invasive Intracranial Pressure Monitoring in Acute Liver Failure- Feasibility, Safety and Impact on Management. Crit Care, 21:178. 2017. PMC5504795

Tiba M, McCracken B, Ansari S, Belle A, Cummings B, Rajajee V, Patil PG, Alam H, Ward K. Novel Noninvasive Method of Cerebrovascular Blood Volume Assessment Using Brain Bioimpedance. J Neurotrauma, 34:3089-3096. 2017. PM28657491

Schroeder KE, Irwin ZT, Bullard A, Thompson D, Bentley JN, Stacey W, Patil PG, Chestek CA. Robust Tactile Sensory Responses in Finger Area of Primate Motor Cortex Relevant to Prosthetic Control. J Neural Eng, 14:046016. 2017. PM28504971/PMC5734857

Chenji G, Wright ML, Chou KL, Seidler RD, Patil PG. Parkinsonian Gait Improves with Bilateral Subthalamic Nucleus Deep Brain Stimulation During Cognitive Multi-Tasking. Parkinsonism Relat Disord, 38:72-79. 2017. PM28258925

Bentley JN, Guan Z, Cummings KS, Chou KL, Patil PG. Influence of Intracranial Air on Electrode Position and Clinical Outcomes Following Deep Brain Stimulation for Parkinson’s Disease. Stereotact Func Neurosurg, 95:6-12. 2017. PM28088795

Glass JD, Hertzberg VS, Boulis NM, Riley J, Federici T, Polak M, Bordeau J, Fournier C, Johe K, Hazel T, Cudkowicz M, Atassi N, Borges LF, Rutkove SB, Duell J, Patil PG, Goutman SA, Feldman EL: Transplantation of spinal cord-derived neural stem cells for ALS: Analysis of phase 1 and 2 trials. Neurology 87(4): 392-400, 2016. PM27358335/PMC4977116

Shah N, Leventhal D, Persad C, Patil PG, Chou KL: A suggested minimum standard deep brain stimulation evaluation for essential tremor. J Neurol Sci 362: 165-8, 2016. PM26944141

Chen KS, McIntyre JC, Lieberman AP, Martens JR, Patil PG: Human spinal autografts of olfactory epithelial stem cells recapitulate donor site histology, maintaining proliferative and differentiation capacity many years after transplantation. Acta Neuropathol 131(4): 639-40, 2016. PM26839081

Irwin ZT, Thompson DE, Schroeder KE, Tat DM, Hassani A, Bullard AJ, Woo SL, Urbanchek MG, Sachs AJ, Cederna PS, Stacey WC, Patil PG, Chestek CA: Enabling Low-Power, Multi-Modal Neural Interfaces Through a Common, Low-Bandwidth Feature Space. IEEE Trans Neural Syst Rehabil Eng 24(5): 521-31, 2016. PM26600160

Schroeder KE, Irwin ZT, Gaidica M, Bentley JN, Patil PG, Mashour GA, Chestek CA: Disruption of corticocortical information transfer during ketamine anesthesia in the primate brain. Neuroimage 134: 459-65, 2016. PM27095309/PMC4912854

Malaga KA, Schroeder KE, Patel PR, Irwin ZT, Thompson DE, Nicole Bentley J, Lempka SF, Chestek CA, Patil PG: Data-driven model comparing the effects of glial scarring and interface interactions on chronic neural recordings in non-human primates. J Neural Eng 13(1): 016010, 2016. PM26655972

Rodrigues B, Patil PG, Chou KL: Thalamic deep brain stimulation for drug-induced tremor. Parkinsonism Relat Disord 21(11): 1369-70, 2015. PM26350120

Hamani C, Pilitsis J, Rughani AI, Rosenow JM, Patil PG, Slavin KS, Abosch A, Eskandar E, Mitchell LS, Kalkanis S: Deep Brain Stimulation for Obsessive-Compulsive Disorder: Systematic Review and Evidence-based Guideline Sponsored by the American Society for Stereotactic and Functional Neurosurgery (ASSFN) and the Congress of Neurological Surgeons (CNS) and Endorsed by the CNS and American Association of Neurological Surgeons (AANS). Neurosurgery 75(4): 327-33, 2014. PM25050579

Hamani C, Pilitsis J, Rughani AI, Rosenow JM, Patil PG, Slavin K, Abosch A, Eskandar E, Mitchell L, Kalkanis S: In Reply: Stereotactic Microanatomy of the Nucleus Accumbens Stimulation for Obsessive-Compulsive Disorder: Reported Coordinates and Mavridis’ Area Neurosurgery 77(1): E156-E157, 2015. PM25938691

Bentley JN, Viswanathan A, Rosenberg WS, Patil PG: Treatment of Medically Refractory Cancer Pain with a Combination of Intrathecal Neuromodulation and Neurosurgical Ablation: Case Series and Literature Review. Pain Medicine 15(9): 1488-95, 2014. PM24931480

Rhew H-G, Jeong J, Fredenburg JA, Dodani S, Patil PG, Flynn MP: A Fully Self-Contained Logarithmic Closed-Loop Deep Brain Stimulation SoC With Wireless Telemetry and Wireless Power Management. IEEE Journal of Solid-State Circuits 49(10): 2213-2227, 2014.

Houshmand L, Cummings KS, Chou KL, Patil PG: Evaluating indirect subthalamic nucleus targeting with validated 3-tesla magnetic resonance imaging Stereotact Funct Neurosurg 92(6): 337-345, 2014. PM25358805

Deer T, Pope J, Hayek S, Narouze S, Patil P, Foreman R, Sharan A, Levy R: Neurostimulation for the treatment of axial back pain: a review of mechanisms, techniques, outcomes, and future advances. Neuromodulation 17 Suppl 2: 52-68, 2014. PM25395117

Coleman RR, Kotagal V, Patil PG, Chou KL: Validity and Efficacy of Screening Algorithms for Assessing Deep Brain Stimulation Candidacy in Parkinson Disease. Mov Disord Clin Pract 1(4): 342-347, 2014. PM25505791/PMC4258408

Soileau MJ, Persad C, Taylor J, Patil PG, Chou KL: Caregiver Burden in Patients with Parkinson Disease Undergoing Deep Brain Stimulation: An Exploratory Analysis. Journal of Parkinson’s Disease 4(3): 517-21, 2014. PM24903924

Chou KL, Taylor JL, Patil PG: The MDS-UPDRS tracks motor and non-motor improvement due to subthalamic nucleus deep brain stimulation in Parkinson disease Parkinsonism Relat. Disord. 19(11): 966-969, 2013. PM23849499

Bentley JN, Chestek C, Stacey WC, Patil PG: Optogenetics in epilepsy Neurosurg Focus 34(6): E4, 2013. PM23724838

Collins KL, Patil PG: Flat-panel fluoroscopy O-arm-guided percutaneous radiofrequency cordotomy: a new technique for the treatment of unilateral cancer pain. Neurosurgery 72(1 Suppl Operative): ons27-ons34, 2013. PM23037818

Patil PG, Conrad EC, Aldridge JW, Chenevert TL, Chou KL: The anatomical and electrophysiological subthalamic nucleus visualized by 3-T magnetic resonance imaging. Neurosurgery 71(6): 1089-1095, 2012. PM22948201

Chou KL, Persad CC, Patil PG: Change in fatigue after bilateral subthalamic nucleus deep brain stimulation for Parkinson’s disease Parkinsonism Relat. Disord. 18(5): 510-513, 2012. PM22341622

Kotagal V, Patil PG, Chou KL: Motor improvement with bilateral subthalamic nucleus deep brain stimulation in a patient with levodopa-responsive secondary parkinsonism Parkinsonism Relat. Disord. 18(1): 79-81, 2012. PM21903443

Wilson TJ, Orringer DA, Sullivan SE, Patil PG: An L-2 burst fracture and cauda equina syndrome due to tetanus: Case report J Neurosurg Spine 16(1): 82-85, 2012. PM21854128

Lu CW, Patil PG, Chestek CA: Current challenges to the clinical translation of brain machine interface technology. Int. Rev. Neurobiol. 107: 137-160, 2012. PM23206681

Collins KL, Taren JA, Patil PG: Four-decade maintenance of analgesia with percutaneous cordotomy. Stereotact Funct Neurosurg 90(4): 266-272, 2012. PM22777513

Rhew H-G, Jeong J, Fredenburg JA, Dodani S, Patil PG, Flynn MP: A Wirelessly Powered Log-Based Closed-Loop Deep Brain Stimulation SoC with Two-Way Wireless Telemetry for Treatment of Neurological Disorders. IEEE Symp VLSI Circuits Digest of Technical Papers 2012: 70-71, 2012.

Coffey MJ, Chou KL, Patil PG: Catatonia during deep brain stimulator implantation complicated by intracranial hemorrhage. Mov. Disord. 25(8): 1097-1098, 2010. PM20222133/PMC

Collins KL, Lehmann EM, Patil PG: Deep brain stimulation for movement disorders. Neurobiol. Dis. 38(3): 338-345, 2010. PM19969083/PMC

Collins KL, Orringer DA, Patil PG: Nanotechnology in Neurosurgery. J Nanotechnol Eng Med 1: 34001-34016, 2010.

Patil PG: Introduction: advances in brain-machine interfaces. Neurosurg Focus 27(1): E1, 2009. PM19569884/PMC

Rohatgi P, Langhals NB, Kipke DR, Patil PG: In vivo performance of a microelectrode neural probe with integrated drug delivery. Neurosurg Focus 27(1): E8, 2009. PM19569896/PMC

Patil PG, Turner DA: The development of brain-machine interface neuroprosthetic devices. Neurotherapeutics 5(1): 137-146, 2008. PM18164493/PMC

Neimat JS, Patil PG, Lozano AM: Novel surgical therapies for Tourette syndrome. J. Child Neurol. 21(8): 715-718, 2006. PM16970873

Patil PG, Neimat J, Lozano AM: Neurosurgical Considerations in the Treatment of Dystonia Contemporary Neurosurgery 28(19): 1-5, 2006.

Patil PG, Turner DA, Pietrobon R: National Trends in Surgical Procedures for Degenerative Cervical Spine Disease: 1990-2000. Neurosurgery 57(4): 753-758; discussion 753-758, 2005. PM16239888

Patil PG, Friedman AH: Surgical Exposure of the Sciatic Nerve in the Gluteal Region: Anatomic and Historical Comparison of Two Approaches. Neurosurgery 56(1 SUPPL.): ONS-165-ONS-170, 2005. PM15799806

Patil PG, Cummings TJ, Nunley JA, Friedman AH: Xanthogranuloma of the Sciatic Nerve: Case Report. Neurosurgery 55(6): 1435, 2004. PM15574230

Patil PG, Carmena JM, Nicolelis MA, Turner DA: Ensemble Recordings of Human Subcortical Neurons as a Source of Motor Control Signals for a Brain-Machine Interface. Neurosurgery 55(1): 27-35, 2004. PM15214971

Carmena JM, Lebedev MA, Crist RE, O’Doherty JE, Santucci DM, Dimitrov DF, Patil PG, Henriquez CS, Nicolelis MA: Learning to Control a Brain-Machine Interface for Reaching and Grasping by Primates. PLoS Biol. 1(2): E42, 2003. PM14624244

Patil PG, Zaas A, Sexton DJ, Frieman AH: Newer Antimicrobials for Neurosurgery. Part II: Current Treatment Guidelines. Contemporary Neurosurgery 24(24): 1-6, 2002.

Patil PG, Zaas A, Sexton DJ, Friedman AH: Newer Antimicrobials for Neurosurgery. Part I: Recently Introduced Agents. Contemporary Neurosurgery 24(23): 1-6, 2002.

Patil PG, Radtke RA, Friedman AH: Newer Anticonvulsants for Neurosurgery. Contemporary Neurosurgery 24(22): 1-6, 2002.

Colecraft HM, Patil PG, Yue DT: Differential occurrence of reluctant openings in G-protein-inhibited N- and P/Q-type calcium channels. J. Gen. Physiol. 115(2): 175-192, 2000. PM10653895

Patil PG, Brody DL, Yue DT: Preferential closed-state inactivation of neuronal calcium channels. Neuron 20(5): 1027-1038, 1998. PM9620706

Brody DL, Patil PG, Mulle JG, Snutch TP, Yue DT: Bursts of action potential waveforms relieve G-protein inhibition of recombinant P/Q-type Ca2+ channels in HEK 293 cells. J. Physiol. (Lond.) 499(3): 637-644, 1997. PM9130160

Jones LP, Patil PG, Snutch TP, Yue DT: G-protein Modulation of N-type Calcium Channel Gating Current in Human Embryonic Kidney Cells (HEK 293). J. Physiol. (Lond.) 498(3): 601-610, 1997. PM9051573

Patil PG, de Leon M, Reed RR, Dubel S, Snutch TP, Yue DT: Elementary Events Underlying Voltage-Dependent G-Protein Inhibition of N-type Calcium Channels. Biophys. J. 71(5): 2509-2521, 1996. PM8913590

Herzig S, Patil P, Neumann J, Staschen C M, Yue D T: Mechanisms of Beta-Adrenergic Stimulation of Cardiac Ca2+ Channels Revealed by Discrete-Time Markov Analysis of Slow Gating. Biophys. J. 65(4): 1599-612, 1993. PM7506067

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Contact Information

Parag Patil, MD PhD
Michigan Medicine
1500 East Medical Center Dr., SPC 5338
Ann Arbor, MI 48109-5338

Office: (734) 936-7010
Fax: (734) 936-9294
pgpatil@med.umich.edu

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